Clinical Series Fleece Liners
The Only All-in-One Guinea Pig Fleece Liner
Stop buying separate fleece liners, pee pads, and waterproof bases. The House of Guineas Clinical Series is a single, all-in-one guinea pig fleece liner with every layer built in — waterproof base, medical-grade absorption core, and soft fleece top. The entire liner is antimicrobial, with silver ion technology throughout that neutralizes ammonia and inhibits bacteria. Pre-activated and ready to use from day one. No prep washes, no piecing together parts from different brands.
$315 for two complete liners — swap while washing, last 6+ years. Designed by an exotic veterinary assistant with an engineering background. Handmade in San Francisco.
Ships from our Etsy shop
Key Features
| Feature | Details |
|---|---|
| All-in-One Design | Waterproof base, absorption core, and fleece top — fully antimicrobial throughout. No separate pads or bases to buy |
| Absorption | Pre-activated to absorb 10x its weight — no 3-5 wash prep cycles needed |
| Antimicrobial | Silver ion technology neutralizes ammonia and inhibits bacterial growth |
| Material | Entirely medical-grade fabric — antimicrobial silver ion technology throughout |
| Sizing | Designed for standard C&C cage setups |
| Includes | Two liners per order — swap while washing |
| Durability | 6+ years with proper care |
| Made In | Handmade in San Francisco, CA |
Why Clinical Series Liners?
Most guinea pig fleece setups require you to buy separate pieces — a fleece liner, absorbent pads underneath, and a waterproof base layer — often from different brands that don’t fit together well. The Clinical Series is an all-in-one solution: every layer is engineered into a single product that’s ready to drop into your C&C cage.
Our liners come pre-activated — they absorb from day one with no prep washes required. The entire liner is antimicrobial — silver ion technology is integrated throughout, not just in one layer. This actively neutralizes ammonia buildup, the primary cause of respiratory irritation in guinea pigs. Combined with the medical-grade fleece surface that wicks moisture away from your pet’s skin, these liners help prevent two of the most common guinea pig health issues: bumblefoot (pododermatitis) and upper respiratory infections.
How They Work
The entire liner is built from medical-grade, antimicrobial fabric with silver ion technology throughout — not just in one layer.
- Top fleece surface — Soft, warm, wicks moisture downward and away from your guinea pig’s feet
- Absorption core — Absorbs 10x its weight in liquid
- Waterproof base — Prevents leaks and protects your cage floor
Every layer is medical-grade. Every layer is antimicrobial.
Guinea Pig Fleece Liners vs Disposable Bedding
| Factor | Clinical Series Fleece Liners | Paper/Wood Shaving Bedding |
|---|---|---|
| Moisture | Wicks away from skin | Traps against skin |
| Odor Control | Antimicrobial silver ion | Saturates in 2-3 days |
| Respiratory Safety | Zero dust, zero airborne irritants | Wood phenols irritate airways |
| Bumblefoot Risk | Low — dry, soft surface | High — damp, rough surface |
| Monthly Cost | $0 after purchase | $20-40/month |
| Annual Cost | $315 one-time (includes 2 liners) | $240-480/year, recurring |
| Prep Required | None — pre-activated | N/A |
| What You Need to Buy | Nothing else — all-in-one design | Just bedding (but frequent restocking) |
| Environmental Impact | Reusable 6+ years | Weekly landfill waste |
| Best for Your Guinea Pig? | Yes — dry, dust-free, antimicrobial | Higher risk of bumblefoot and URIs |
Care Instructions
Maintaining your Clinical Series fleece cage liners is simple:
- Daily: Spot clean by sweeping off hay and removing droppings
- Weekly: Machine wash on warm cycle with gentle, fragrance-free detergent
- Drying: Tumble dry on low heat
- Avoid: Fabric softener (reduces wicking ability), bleach, and high heat
- Swap: Use your second liner while the first is in the wash
With proper care, each liner pair lasts 6+ years.
Frequently Asked Questions
Do I need to prep the liners before first use?
No. Unlike most guinea pig fleece liners that require 3-5 wash cycles before they start wicking properly, our Clinical Series liners come pre-activated and are ready to absorb right out of the box.
What size C&C cage do they fit?
Our liners are sized for standard C&C cage configurations — the most popular guinea pig housing recommended by rescue organizations. If you have a custom setup, contact us and we can discuss options.
How often should I wash the liners?
We recommend washing weekly. Spot clean daily by removing hay and droppings. When it's wash day, simply swap to your second liner while the first goes through the machine. Warm wash, gentle detergent, tumble dry low. No fabric softener.
Are fleece liners safe for baby guinea pigs?
Yes — fleece is actually safer for baby guinea pigs than loose bedding, which young pigs may accidentally ingest. Our medical-grade fleece provides a soft, warm surface that's gentle on tiny feet.
What is silver ion antimicrobial technology?
Silver ions (Ag+) have natural antimicrobial properties that disrupt bacterial cell membranes. In our liners, silver ion technology is integrated throughout the entire fabric — not just a single layer — to actively neutralize ammonia and inhibit bacterial growth between washes. This keeps your guinea pig's enclosure cleaner and healthier for longer.
Can I use these liners for rabbits or chinchillas?
While designed for guinea pigs, the Clinical Series liners work well for rabbits and chinchillas too. The antimicrobial properties and absorption capacity benefit any small mammal. Just ensure the sizing works for your enclosure.
Do I need to buy separate pee pads or waterproof bases?
No. Unlike most fleece liner setups where you need to buy a fleece liner, separate absorbent pads, and a waterproof base layer — often from different brands — the Clinical Series is an all-in-one design. The waterproof base, absorption core, and fleece top are all built into a single product, and the entire liner is antimicrobial with silver ion technology throughout. Just place it in your cage and you're done.
How are these different from GuineaDad liners?
The Clinical Series is a complete all-in-one liner — you don't need to buy separate pee pads or accessories. The entire fabric is medical-grade with antimicrobial silver ion technology throughout (not just one layer), actively neutralizing ammonia — a feature not found in GuineaDad or other standard fleece liners. Our liners also come pre-activated (no 3-5 prep washes), last 6+ years, and are handmade in San Francisco by an exotic veterinary assistant with an engineering background.
Read our full comparison: Guinea Pig Fleece Liners vs Disposable Bedding.
The only all-in-one, pre-activated, antimicrobial guinea pig fleece liner — handmade in San Francisco, California.
Ready to stop piecing together bedding from different brands?
Order Your Liners — $315 for Two More Small Pet Resources
Ships from our Etsy shop